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FAKULTÄT FÜR BIOLOGIE, CHEMIE UND GEOWISSENSCHAFTEN

Organische Chemie I - Prof. Dr. Rainer Schobert

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Publikationen

2019
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    204) Farhan M., Malik A., Ullah M.F., Afaq S., Faisal M., Farooqi A.A., Biersack B., Schobert R. Ahmad A.
    Garcinol sensitizes NSCLC cells to standard therapies by regulating EMT-modulating miRNAs
    Int J Mol Sci, 20, 2019, xxx−xxx

    203) Dankhoff K., Ahmad A., Weber B., Biersack B., Schobert R.
    Anticancer properties of a new non-oxido vanadium(IV) complex with a catechol-modified 3,3'-diindolylmethane ligand
    J Inorg Biochem, 193, 2019, xxx−xxx

    202) Ahmad A., Dandawate P., Schrüfer S., Padhye S., Sarkar F.H., Schobert R., Biersack B.
    Pentafluorophenyl substitution of natural di(indol-3-yl)methane strongly enhances growth inhibition and apoptosis induction in various cancer cell lines
    Chem Biodiv, 16, 2019, DOI: 10.1002/cbdv.201900028

    201) Schmitt F., Gosch L.C., Dittmer A., Müller T., Schobert R., Biersack B., Volkamer A., Höpfner M.
    Oxazole-bridged combretastatin A-4 derivatives with tethered hydroxamic acids: Structure-activity relations of new inhibitors of HDAC and/or tubulin function
    Int J Mol Sci, 20, 2019, 83−408

    200) Schmitt F., Gold M., Rothemund M., Andronache I., Biersack B., Schobert R., Müller T.
    New naphthopyran analogues of LY290181 as potential tumor vascular-disrupting agents
    Eur J Med Chem, 163, 2019, 160−168

    199) Petermichl M., Steinert C., Schobert R.
    A synthetic route to the MT1-MMP inhibitor ancorinoside D
    Synthesis, 51, 2019, 730−738.

    198) Rieß M., Senker J., Schobert R., Breu J.
    Microporous organically pillared layered silicates (MOPS) − a versatile class of functional porous materials
    Chem Eur J, 25, 2019, 2103−2111

2018
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    197) Rehm T., Rothemund M., Bär A., Dietel T., Kempe R., Kostrhunova H., Brabec V., Kasparkova J., Schobert R.
    N,N-Dialkylbenzimidazol-2-ylidene platinum complexes − effects of alkyl residues and ancillary cis-ligands on their anticancer activity
    Dalton Trans, 47, 2018, 17357−17381

    196) Bruckner S., Weise M., Schobert R.
    Synthesis of the entomopathogenic fungus metabolites militarinone C and fumosorinone A
    J Org Chem, 83, 2018, 10805−10812.

    195) Müller T., Biersack B., Lutzkendorf J., Müller L.P., Schobert R.
    Brimamin - a combretastatin A-4 derived N-methylimidazole overcomes drug resistance and inhibits metastasis in xenograft models of colorectal cancer A
    Oncol Res Treat, 14, 2018, Supp. 4, 111−112

    194) Ortega E., Yellol J.G., Rothemund M., Ballester F.J., Rodriguez V., Yellol G., Janiak C., Schobert R., Ruiz J.
    A new C,N-cyclometalated osmium(II) arene anticancer scaffold with a handle for functionalization and antioxidative properties
    Chem Commun, 54, 2018, 11120−11123

    193) Curran D., Dada O., Müller-Bunz H., Rothemund M., Sánchez-Sanz G., Schobert R., Zhu X., Tacke M.
    Synthesis and cytotoxicity studies of novel NHC*-gold(I) complexes derived from lepidiline A
    Molecules, 23, 2018, 2031.

    192) Hahn L., Lübtow M.M., Lorson T., Schmitt F., Appelt-Menzel A., Schobert R., Luxenhofer R.
    Investigating the influence of aromatic moieties on the formulation of hydrophobic natural products and drugs in poly(2-oxazoline) based amphiphiles
    Biomacromolecules, 19, 2018, 3119−3128.

    191) Wunder A., Rothemund M., Schobert R.
    Synthesis and anticancer activity of the proposed structure of caldoramide, an N-peptidyl-tetramate from the cyanobacterium Caldora Penicillata
    Tetrahedron, 74, 2018, 5138−5142.

    190) Schmitt F., Kasparkova J., Brabec V., Begemann G., Biersack B., Schobert R.
    New (arene)ruthenium(II) complexes of 4-aryl-4H-naphthopyrans with anticancer and anti-vascular activities
    J Inorg Biochem, 184, 2018, 69−78.

    189) Schmitt F., Subramaniam D., Anant S., Padhye S., Begemann G., Schobert R., Biersack B.
    Halogenated bis(methoxybenzylidene)-4-piperidone curcuminoids with improved anticancer activity
    ChemMedChem, 13, 2018, 1115−1123.

    188) Schobert R., Biersack B.
    Multimodal HDAC inhibitors with improved anticancer activity
    Current Cancer Drug Targets, 18, 2018, 39−56.

    187) Biersack B., Ahmed K., Padhye S., Schobert R.
    Recent developments concerning the application of the Mannich reaction for drug design
    Exp Op Drug Disc, 13, 2018, 39−49.

2017
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    186) Lovmo K., Duetz S., Harras M., Haase R.G., Milius W., Schobert R.
    A short synthesis of 3-enoyltetramic acids employing a new acyl ylide conjugate of Meldrum's acid
    Tetrahedron Lett, 58, 2017, 4796−4798.

    185) Kempf O., Kempf K., Schobert R., Bombarda E.
    Hydrodabcyl: a superior hydrophylic alternative to the dark fluorescence quencher dabcyl
    Analytical Chem, 89, 2017, 11893−11897.

    184) Petermichl M., Schobert R.
    Total synthesis of the diglycosidic tetramic acid ancorinoside A
    Chem Eur J, 23, 2017, 14743−14746.

    183) Linder D., Schobert R.
    Synthesis of the fungus metabolite cladosin C
    Org Biomol Chem, 15, 2017, 7672−7677.

    182) Steinemann S.G., Josuttis D., Dittmer A., Kuzyniak W., Hoffmann B., Schrader M., Schobert R., Biersack B., Nitzsche B., Höpfner M.
    Animacroxam, a novel dual-mode compound targeting histone deacetylases and cytoskeletal integrity of testicular germ cell cancer cells
    Mol Cancer Ther, 16, 2017, 2364−2374.

    181) Schmidt R., Ostermeier M., Schobert R.
    Wittig cyclization of ω-hydroxy hemiacetals: Synthesis of (+) aspicilin
    J Org Chem, 82, 2017, 9126−9132.

    180) Kempf K., Kempf O., Orozco M., Bilitewski U., Schobert R.
    Synthesis and structural revision of the fungal tetramic acid metabolite spiroscytalin
    J Org Chem, 82, 2017, 7791−7795.

    179) Schmitt F., Gold M., Begemann G., Andronache I., Biersack B., Schobert R.
    Fluoro and pentafluorothio analogs of the antitumoral curcuminoid EF24 with superior antiangiogenic and vascular-disruptive effects
    Bioorg Med Chem, 25, 2017, 4894−4903.

    178) Winter I., Lockhauserbäumer J., Lallinger-Kube G., Schobert R., Ersfeld K., Biersack B.
    Anti-trypanosomal activity of cationic heterocyclic carbene gold(I) complexes
    Mol Biochem Parasit, 214, 2017, 112−120.

    177) Bilitewski U., Blodgett, J.A.V., Duhme-Klair A.-K., Dellavalle S., Laschat S., Routledge A., Schobert R.
    Chemical and biological aspects of nutritional immunity − perspectives for new anti-infectives targeting iron uptake systems
    Angew Chem, 129, 2017, 14552−14575 / IE:, 56, 2017, 14360−14382.

    176) Bruckner S., Haase R.G., Schobert R.
    A synthetic route to β-hydroxytyrosine derived tetramic acids: total synthesis of the fungal metabolite F−14329
    Chem Eur J, 23, 2017, 5692−5695.

    175) Zamora A., Perez S.A., Rothemund M., Rodriguez V., Schobert R., Janiak C., Ruiz J.
    Exploring the influence of the aromaticity on the anticancer and anti-vascular activities of organoplatinum(II) complexes
    Chem Eur J, 23, 2017, 5614−5625.

    174) Shuveksh P.S., Ahmed K., Padhye S., Schobert R., Biersack B.
    Chemical and biological aspects of the natural 1,4-benzoquinone embelin and its (semi-)synthetic derivatives
    Curr Med Chem, 24, 2017, 1998−2009.

    173) Lohmann G., Vasyutina E., Blöhdorn J., Reinart N., Schneider J., Babu V., Knittel G., Mayer P., Prinz C., Biersack B., Münzner J.K., Efremov D.G., Chessa L., Herling C.D., Stilgenbauer S., Hallek M., Schobert R., Reinhardt C., Schumacher B., Herling M.,
    Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia
    Leukemia, 312017, 1177−1186.

    172) Draut H., Rehm T., Begemann G., Schobert R.,
    Evaluation of genistein, daidzein, usnic acid, and their copper complexes for angiogenicity in zebrafish
    Chem Biodivers, 14, 2017, e1600302.

    171) Petermichl M., Schobert R.,
    3-Acyltetramic acids: a decades-long approach to a fascinating natural product family
    Synlett, 28, 2017, 654−663.

    170) Herling M.H., Lacher U., Rieß M., Seibt S., Schwedes M., Kalo H., Schobert R., Breu J.,
    Sub-micron pore size tailoring for efficient chiral discrimination
    Chem Commun, 53, 2017, 1072−1075.

    169) Harras M., Milius W., Aitken R.A., Schobert R.,
    Synthesis of combretastatins D-1, D-2, and D-4 via ring contraction by flash vacuum pyrolysis
    J Org Chem, 82, 2017, 579−587.

    168) Mahal K., Ahmad A., Schmitt F., Lockhauserbäumer J., Starz K., Pradhan R., Padhye S., Sarkar F.H., Koko W.S., Schobert R., Ersfeld K., Biersack B.,
    Improved anticancer and antiparasitic activity of new lawsone Mannich bases
    Eur J Med Chem, 126, 2017, 421−431.

    167) Ahmad A., Mahal K., Padhye S., Sarkar F.H., Schobert R., Biersack B.,
    New ferrocene modified lawsone Mannich bases with anti-proliferative activity against tumor cells
    J Saudi Chem Soc, 21, 2017, 105−110.

2016
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    166) Münzner J.K., Biersack B., Albrecht A., Rehm T., Lacher U., Milius W., Casini A., Zhang J.-J., Ott I., Brabec V., Stuchlikova O., Andronache I. C., Kaps L., Schuppan D., Schobert R. (2016),
    Ferrocenyl-coupled N-heterocyclic carbene complexes of gold(I): a successful approach to multinuclear anticancer drugs
    Chem Eur J, 22, 2016, 18953−18962.

    165) Haase R.G., Schobert R.,
    Synthesis of the bioherbicidal fungus metabolite macrocidin A
    Org Lett, 18, 2016, 6352−6355.

    164) Linder D., Schobert R.,
    A short synthesis of the mould metabolite (R)-(+)-carolinic acid from (S)-lactic acid
    Synthesis, 48, 2016, 4564−4568.

    163) Schmitt F., Draut H., Biersack B., Schobert R.,
    New halogenated naphthochalcones and structurally related naphthopyrazolines with antitumor activity
    Bioorg Med Chem Lett, 26, 2016, 5168−5171.

    162) Wunder A., Schobert R.,
    An expeditious synthesis of the ascomycete metabolite rigidiusculamide B
    Org Biomol Chem, 14, 2016, 9262−9266.

    161) Schmitt F., Donnelly K., Münzner J.K., Rehm T., Novohradsky V., Brabec V., Kasparkova J., Albrecht M., Schobert R., Müller T.,
    Effects of histidin-2-ylidene vs. imidazol-2-ylidene ligands on the anticancer and antivascular activity of complexes of ruthenium, iridium, platinum, and gold
    J Inorg Biochem, 163, 2016, 221−228.

    160) Rehm T., Rothemund M., Münzner J.K., Noor A., Kempe R., Schobert R.,
    Novel cis-[(NHC1)(NHC2)]platinum(II) complexes − synthesis and anti-cancer activities
    Dalton Trans, 45, 2016, 15390−15398.

    159) Winterer M., Kempf K., Schobert R.,
    Synthesis of an isomer of the decalinoyltetramic acid methiosetin by a stereocontrolled IMDA reaction of a metal chelated 3-trienoyltetramate
    J Org Chem, 81, 2016, 7336−7341.

    158) Petermichl M., Loscher S., Schobert R.,
    Total synthesis of aurantoside G, an N-β-glycosylated 3-oligoenoyltetramic acid from Theonella swinhoei
    Angew Chem, 128, 2016, 10276−10279 / IE: 55, 10122−10125.

    157) Zhang L. J.-J., Münzner J.K., Abu el Maaty M., Karge B., Schobert R., Wölfl S., Ott I.,
    A multi-target caffeine derived rhodium(I) N-heterocyclic carbene complex: evaluation of the mechanism of action
    Dalton Trans, 45, 2016, 13161−13168.

    156) Münzner J.K., Ahmad A., Rothemund M., Schrüfer S., Padhye S., Sarkar F.H., Schobert R., Biersack B.,
    Ferrocene substituted 3,3'-diindolylmethanes with improved anticancer activity
    Appl Organomet Chem, 30, 2016, 441-445.

    155) Mahal K., Biersack B., Schrüfer S., Resch M., Ficner R., Schobert R., Müller T.,
    Combretastatin A-4 derived 5-(1-methyl-4-phenyl-imidazol-5-yl) indoles with superior cytotoxic and anti-vascular effects on chemoresistant cancer cells and tumors
    Eur J Med Chem, 118, 2016, 9−20.

    154) Spörlein-Güttler C., Milius W., Obenauf J., Schobert R.,
    Oxidation of 2,3-dihydrowogonin to negletein via an extended Wessely-Moser rearrangement
    Tetrahedron Lett., 57, 2016, 1560.

    153) Bruckner S., Bilitewski U., Schobert R.,
    Synthesis and antibacterial activity of four stereoisomers of the spider-pathogenic fungus metabolite torrubiellone D
    Org. Lett., 18, 2016, 1136.

    152) Loke I., Bentzinger G., Holz J., Raja A., Bhasin A., Sasse F., Schobert R., Laschat S.,
    Synthesis of the AB ring system of clifednamide utilizing Claisen rearrangement and Diels-Alder reaction as key steps
    Org. Biomol. Chem., 14, 2016, 884.

2015
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    151) Mahal K., Ahmad A., Sethi S., Resch M., Ficner R., Sarkar F.H., Schobert R., Biersack B.,
    Role of JNK and NF-κB in mediating the effect of combretastatin A-4 and brimamin on endothelial and carcinoma cells
    Cell. Oncol., 38, 2015, 463.

    150) Münzner J.K., Rehm T., Biersack B., Casini A., deGraf I.A.M., Worawutputtapong P., Noor A., Kempe R., Brabec V., Kasperkova J. Schobert R.,
    Adjusting the DNA interaction and anticancer activity of Pt(II) N-heterocyclic carbene complexes by steric shielding of the trans leaving group
    J. Med. Chem., 58, 2015, 6283.

    149) Mahal K., Kahlen P., Biersack B., Schobert R.,
    4-(1-Ethyl-4-anisyl-imidazol-5-yl)-N-hydroxycinnamide - A new pleiotropic HDAC inhibitor targeting cancer cell signalling and cytoskeletal organisation
    Exp. Cell. Res., 336, 2015, 263.

    148) Kempf K., Schmitt F., Bilitewski U., Schobert R.,
    Synthesis, stereochemical assignment, and bioactivity of the Penicillium metabolites penicillenols B1 and B2
    Tetrahedron, 71, 2015, 5064.

    147) Seutter von Loetzen C., Jacob T., Hartl-Spiegelhauer O., Vogel L., Schiller D., Spörlein-Güttler C., Schobert R., Vieths S., Hartl M.H., Roesch P.,
    Ligand recognition of the major birch pollen allergen Bet v 1 is isoform dependent
    PloS One, 10(6), 2015, e0128677.

    146) Mahal K., Biersack B., Caysa H., Schobert R., Müller T.,
    Combretastatin A-4 derived from imidazoles show cytotoxic, antivascular and antimetastatic effects based on cytoskeletal reorganisation
    Invest. New Drugs, 33, 2015, 541.

    145) Stöter M., Biersack B., Rosenfeldt S., Leitl M.J., Kalo H., Schobert R., Yersin H., Ozin G.A., Förster S., Breu J.,
    Nanoglas-Verkapselung funktionaler organischer Verbindungen für optisch anisotrope Beschichtungen
    Angew. Chem., 127, 2015, 5047.

    144) Mahal K., Schrüfer S., Steinemann G., Rausch F., Schobert R., Biersack B., Hoepfner M.,
    Biological evaluation of 4,5-diarylimidazoles with hydroxamic acid appendages as novel dual mode anticancer agents
    Cancer Chemother. Pharmacol., 75, 2015, 691.

    143) Di Fazio P., Lingelbach S., Schobert R., Biersack B.,
    4,5-Diaryl imidazoles with hydroxamic acid appendages as anti-hepatoma agents
    Invest. New Drugs, 33, 2015, 104.

2014
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    142) Vieweg L., Reichau S., Schobert R., Leadlay P.F., Süssmuth, R.D.,
    Recent advances in the field of bioactive tetronates
    Nat. Prod. Rep., 31, 2014, 1554.

    141) Stöter M., Biersack B., Reimer N., Herling M., Stock N.,Schobert R., Breu J.,
    Ordered Heterostructures of Two Strictly Alternating Types of Nanoreactors
    Chem. Mater., 26, 2014, 2412.

    140) Effenberger-Neidnicht K., Schobert R., Biersack B.,
    Synthesis and anticancer activity of (6-aminomethylnicotinate)dichloridoplatinum(II) conjugates with lupane-type triterpenes
    J. Pharm. Sci. Pharmacol., 1, 2014, 237.

    139) Mahal K., Schill E., Breyer S., Pachmann U., Pachmann K., Schobert R., Biersack B.
    Activity of a doxorubicin menthol conjugate against circulating epithelial tumor cells of cancer patients
    J. Pharm. Sci. Pharmacol., 1, 2014, 233.

    138) Schmidt H., Günther C., Weber M., Spörlein, C., Loscher S., Böttcher C., Schobert R., Clemens S.,
    Metabolone analysis of Arabidopsis thaliana roots identifies a key metabolic pathway for iron aquisition
    PLoS ONE, 9(7), 2014, e102444.

    137) Spörlein-Güttler C., Mahal K., Schobert R., Biersack B.,
    Ferrocene and (arene)ruthenium(II) complexes of the natural anticancer naphthoquinone plumbagin with enhanced efficacy against resistant cancer cells and a genuine mode of action
    J. Inorg. Biochem., 138, 2014, 64.

    136) Münzner J.K., Biersack B., Kalie H., Andronache I.C., Kaps L., Schuppan D., Sasse F., Schobert R.,
    Gold(I) Biscarbene complexes derived from vascular-disrupting combretastatin A-4 address diffenrent targets and show antimetastatic potential
    Chem. Med. Chem., 9, 2014, 1195.

    135) Ostermeier M., Schobert R.,
    Total synthesis of (+)-chloriolide
    J. Org. Chem., 79, 2014, 4038.

    134) Diar-Bakerly B., Hirsemann D., Kalo H., Schobert R., Breu J.,
    Modification of kaolinite by grafting of siderophilic ligands to the external octahedral surface
    Appl. Clay Sci., 90, 2014, 67.

    133) Mahal K., Resch M., Ficner R., Schobert R., Biersack B., Müller T.,
    Effects of the tumor vasculature-disrupting agent verubulin and two heteroaryl analogues on cancer cells, endothelial cells and blood vessels
    Chem. Med. Chem., 9, 2014, 847.

2013
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    132) Spörlein C., Mahal K., Schmidt H., Schobert R.,
    Effects of chrysin, apigenin, genistein and their homoleptic copper(II) complexes on the growth and metastatic potential of cancer cells
    J. Inorg. Biochem., 127, 2013, 107.

    131) Krebs M., Kalinowski M., Frey W., Claasen B., Baro A., Schobert R., Laschat S.,
    Tricyclic challenges: synthetic approaches toward dodecahydrocyclopenta[a]indenes
    Tetrahedron, 69, 2013, 7373.

    130) Loscher S., Schobert R.,
    Total synthesis and absolute configuration of epicoccamide D, a naturally occurring mannosylated 3-acyltetramic acid
    Chemistry, 19, 2013, 10619.

    129) Harras M., Bauer T., Kempe R., Schobert R.,
    Selective O-methylations of 3-[(triphenylphosphoranylidene)acetyl]tetronic and -tetramic acids
    Tetrahedron, 69, 2013, 3677.

    128) Beneke J., Schobert R.,
    α-Carboxy-,β-Lactones from Photoinduced Ring Contraction of 3-Diazodihydrofuran-2,4-diones
    Synthesis, 45, 2013, 773.

    127) Kempf K., Raja A., Sasse F., Schobert R.,
    Synthesis of Penicillenol C1 and of a Bis-Azide Analogue for Photoaffinity Labeling
    J. Org. Chem., 78, 2013, 2455.

    126) Ahmad A., Biersack B., Li Y., Bao B., Kong D., Schobert R., Padhye S.B., Sarkar F.,
    Deregulation of PI3K/Akt/mTOR Signaling Pathways by Isoflavones and its Implication in Cancer Treatment
    Anticancer Agents Med. Chem., 13, 2013, 1014.

    125) Ahmad A., Biersack B., Li Y., Kong D.,  Bao B., Schobert R., Padhye S.B., Sarkar F. H.,
    Targeted Regulation of PI3K/Akt/mTOR/NF-κB Signaling by Indole Compounds and their Derivatives: Mechanistic Details and Biological Implications for Cancer Therapy
    Anticancer Agents Med. Chem., 13, 2013, 1002.

    124) Münzner J.K., Biersack B., Kaps L., Schobert R., Sasse F.,
    Synergistic "gold effects" of anti-vascular 4,5-diarylimidazol-2-ylidene gold(I) carbene complexes
    Int. J. Clin. Pharmacol. Ther., 51, 2013, 44.

    123) Mahal, K., Biersack B., Schobert R.,
    New oxazole-bridged combretastatin A-4 analogues as potential vascular-disrupting agents
    Int. J. Clin. Pharmacol. Ther., 51, 2013, 41.

2012
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    122) Pradhan R., Dandawate P., Vyas A., Padhye S., Biersack B., Schobert R., Ahmad A., Sarkar F. H.,
    From Body Art to Anticancer Activities: Perspectives on Medicinal Properties of Henna
    Curr. Drug Targets, 13, 2012, 1777.

    121) Biersack B., Schobert R.,
    Indole Compounds against Breast Cancer: Recent Developments
    Curr. Drug Targets, 13, 2012, 1705.

    120) Herling M.M., Kalo H., Seibt S., Schobert R., Breu J.,
    Tailoring the Pore Sizes of Microporous Pillared Interlayered Clays through Layer Charge Reduction
    Langmuir., 28, 2012, 14713.

    119) Ahmad A., Sarkar S.H., Aboukameel, A., Ali S., Biersack B., Seibt S., Li Y., Bao B., Kong D., Banerjee S., Schobert R., Padhye S.B., Sarkar F.H.,
    Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling
    Carcinogenesis, 33, 2012, 2450.

    118) Biersack B., Ahmad A., Sarkar F.H., Schobert R.,
    Coinage Metal Complexes Against Breast Cancer
    Curr. Med. Chem., 19, 2012, 3949.

    117) Hirsemann D., Shylesh S., De Souza R. A., Diar-Bakerly B., Biersack B., Mueller D. N., Martin M., Schobert R., Breu J.,
    Large-scale, low-cost fabrication of janus-type emulsifiers by selective decoration of natural kaolinite platelets
    Angew. Chem., 124, 2012, 1376.
    Angew. Chem. Int. Ed., 51, 2012, 1348.

    116) Effenberger-Neidnicht K., Breyer S., Mahal K., Sasse F., Schobert R.,
    Modification of uptake and subcellular distribution of doxorubicin by N-acylhydrazone residues as visualised by intrinsic fluorescence
    Cancer Chemother. Pharmacol., 69, 2012, 85.

    115) Kaps L., Biersack B., Müller-Bunz H., Mahal K., Münzner J.K., Tacke M., Müller T., Schobert R.,
    Gold(I)-NHC complexes of antitumoral diarylimidazoles: Structures, cellular uptake and anticancer activities
    J. Inorg. Biochem., 102, 2012, 52.

    114) Loke I., Park N., Kempf K., Jagusch C., Schobert R., Laschat S.,
    Influence of steric parameters on the synthesis of tetramates from α-amino-β-alkoxy-esters and Ph3PCCO
    Tetrahedron, 68, 2012, 697.

2011
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    113) Osowole A.A., Kempe R., Schobert R., Effenberger K.,
    Synthesis, spectroscopic, thermal, and in vitro anticancer properties of some M(II) complexes of 3-(-1-(4,6-dimethyl-2-pyrimidinylimino)methyl-2-naphthol
    Synthesis and Reactivity in Inorganic Metal-Organic and Nano-Metal Chemistry, 41, 2011, 825.

    112) Schobert R., Biersack B., Caysa H., Sasse F., Reipsch F., Müller T.,
    Characterisation of new vascular-disrupting agents with high antitumor activity
    Onkologie, 34(suppl 6), 2011, 49.

    111) Biersack B., Dietrich A., Zoldakova M., Kalinowski B., Paschke R., Schobert R., Müller T.,
    Lipophilic Pt(II) complexes with selective efficacy against cisplatin-resistant testicular cancer cells
    J. Inorg. Biochem., 105, 2011, 1630.

    110) Biersack B., Muthukumar Y., Schobert R., Sasse F.,
    Cytotoxic and antivascular 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(halophenyl)-imidazoles
    Bioorg. Med. Chem. Lett., 21, 2011, 6270.

    109) Patila S., Deally A., Hackenberg, F., Kaps L., Müller-Bunz H., Schobert R., Tacke M.,
    Novel benzyl- or p-cyanobenzyl-substituted N-heterocyclic carbene-silver(I) bromide and gold(I) chloride complexes: synthesis and preliminary cytotoxicity studies
    Helv. Chim. Acta, 94, 2011, 1551.

    108) Schobert R., Seibt S., Mahal K., Ahmad A., Biersack B., Effenberger-Neidnicht K., Padhye S., Sarkar F. H., Müller T.,
    Cancer selective metallocenedicarboxylates of the fungal cytotoxin illudin M
    J. Med. Chem., 54, 2011, 6177.

    107) Zoldakova M., Biersack B., Kostrhunova H., Ahmad A., Padhye S., Sarkar F. H., Schobert R., Brabec V.,
    (Carboxydiamine)Pt(II) complexes of a combretastatin A-4 analogous chalcone: the influence of the diamine ligand on DNA binding and anticancer effects
    MedChemComm., 2, 2011, 493.

    106) Effenberger-Neidnicht K., Breyer S., Mahal K., Diestel R., Sasse F., Schobert R.,
    Cellular Localisation of Antitumoral 6-Alkyl Thymoquinones via an Alkyne-Azide Click Reaction and the Streptavidin-Biotin System.
    ChemBioChem., 12, 2011, 1237.

    105) Effenberger-Neidnicht K., Schobert R.,
    Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin.
    Cancer Chemother. Pharmacol., 67, 2011, 867.

    104) Schobert R., Seibt S., Effenberger-Neidnicht K., Underhill C., Biersack B., Hammond G. L.,
    (Arene)Cl(2)Ru(II) complexes with N-coordinated estrogen and androgen isonicotinates: interaction with sex hormone binding globulin and anticancer activity.
    Steroids, 76, 2011, 393.

    103) Breyer S., Effenberger-Neidnicht K., Knauer S., Schobert R.,
    Synthesis, anticancer activity, and iron affinity of the Actinoplanes metabolite 7,8-dihdroxy-1-methylnaphtho[2,3-c]furan-4,9-dione
    Bioorg. Med. Chem., 19, 2011, 1264.

    102) Schobert R., Effenberger-Neidnicht K., Biersack B.,
    Stable combretastatin A-4 analogues with sub-nanomolar efficacy against chemoresistant HT-29 cells
    Int. J. Clin. Pharmacol. Ther., 49, 2011, 71.

    101) Schobert R., Knauer S., Seibt S., Biersack B.,
    Anticancer active illudins: recent developments of a potent alkylating compound class
    Curr. Med. Chem., 18, 2011, 790.

    100) Gmeiner A., Effenberger-Neidnicht K., Zoldakova M., Schobert R.,
    A methyltitanocene complex of schisandrol A with high efficacy against multi-drug resistant cervix and breast carcinoma cells
    Appl. Organomet. Chem., 25, 2011, 117.

2010
Einklappen

    99)  Barnickel B., Bayliffe F., Diestel R., Kempf K., Laschat S., Pachali S., Sasse F., Schlenk A., Schobert R.,
    Structure-Activity Relationships of Precursors and Analogs of Natural 3-Enoyl-tetramic Acids.
    Chem. Biodiv., 7, 2010, 2830.

    98)  Zoldakova M., Kornyei Z., Brown A., Biersack B., Madarasz E., Schobert R.,
    Effects of a combretastatin A4 analogous chalcone and its Pt-complex on cancer cells: a comparative study of uptake, cell cycle and damage to cellular compartments.
    Biochem. Pharmacol., 80, 2010, 1487.

    97)  Biersack B., Effenberger K., Knauer S., Ocker M., Schobert R.,
    Ru(η6-arene) complexes of combretastatin-analogous oxazoles with enhanced anti-tumoural impact
    Eur. J. Med. Chem., 45, 2010, 4890.

    96)  Barnickel B., Schobert R.,
    Towards the macrocidins: macrocyclization via Williamson etherification of a phenolate.
    J. Org. Chem., 75, 2010, 6716.

    95)  Schobert R., Biersack B., Dietrich A., Effenberger K., Knauer S., Müller T.,
    4-(3-Halo/amino-4,5-dimethoxy-phenyl)-5-aryl-oxazoles and -N-methylimidazoles that are cytotoxic against combretastatin A resistant tumor cells and vascular disrupting in a cisplatin resistant germ cell tumor model
    J. Med. Chem., 53, 2010, 6595.

    94)  Breyer S., Effenberger-Neidnicht K., Schobert R.,
    Total Synthesis and Anticancer Activities of (-)- and (+)-Thespesone
    J. Org. Chem., 75, 2010, 6214.

    93)  Effenberger K., Breyer S., Ocker M., Schobert R.,
    New doxorubicin N-acyl hydrazones with improved efficacy and cell line specificity show modes of action different from the parent drug
    Int.  J. Clin. Pharmacol. Therapeutics, 48, 2010, 485.

    92)  Schobert R., Sasse F., Biersack B., Effenberger K., Breyer S., Diestel R.,
    Tumor-selective amphiphilic paraquinones and tetramic acids.
    Int. J. Clin. Pharmacol. Therapeutics, 48, 2010, 459.

    91)  Effenberger K., Breyer S., Schobert R.,
    Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones
    Eur. J. Med. Chem., 45, 2010, 1947.

    90)  Biersack B., Zoldakova M., Effenberger K., Schobert R.,
    (Arene) Ru(II) complexes of epidermal growth factor receptor inhibiting tyrphostins with enhanced selectivity and cytotoxicity in cancer cells
    Eur. J. Med. Chem., 45, 2010, 1972.

    89)  Biersack B., Effenberger K., Schobert R., Ocker, M.,
    Oxazole-bridged combretastatin A analogues with improved anticancer properties
    Chem. Med. Chem., 5, 2010, 420.

    88)  Schlenk, A., Diestel, R., Sasse, F., Schobert, R.,
    A Selective 3-Acylation of Tetramic Acids and the First Synthesis of Ravenic Acid
    Chem. Eur. J., 16, 2010, 2599.

    87)  Wirries A., Breyer S., Quint K., Schobert R., Ocker M.,
    Thymoquinone hydrazone derivatives cause cell cycle arrest in p53-competent colorectal cancer cells
    Exp. Ther. Med., 1, 2010, 369.

    86)  Effenberger K., Breyer S., Schobert R.,
    Terpene Conjugates of the Nigella sativa Seed-Oil Constituent Thymoquinone with Enhanced Efficacy in Cancer Cells
    Chemistry & Biodiversity, 7, 2010, 129.

Ältere
Einklappen

    85)  Schobert R., Barnickel B.,
    A regioselective Tsuji-Trost pentadienylation of 3-allyltetronic acid
    Synthesis, , 2009, 2778.

    84)  Knauer S., Biersack B., Zoldakova M., Effenberger K., Milius W., Schobert R.,
    Melanoma-specific ferrocene esters of the fungal cytotoxin illudin M
    Anti-Cancer Drugs, 20(8), 2009, 676.

    83)  Pachali S., Hofmann C., Rapp G., Schobert R., Baro A., Frey W., Laschat S.,
    Stereoselective Synthesis of (2E,4Z)-Dienamides Employing (Triphenylphosphoranylidene) ketene
    Eur. J. Org. Chem., , 2009, 2828.

    82)  Biersack B., Schobert R.,
    Metallodrug Conjugates with Steroids and Selective Estrogen Receptor Modulators (SERM)
    Current  Med. Chem., 16, 2009, 2324.

    81)  Breyer S., Effenberger K., Schobert R.,
    Effects of Thymoquinone-Fatty Acid Conjugates on Cancer Cells
    Chem. Med. Chem., 4, 2009, 761.

    80)  Schobert R., Biersack B., Dietrich A., Knauer S., Zoldakova M., Fruehauf A., Mueller T.,
    Pt(II) complexes of a Combretastatin A-4 Analogous Chalcone: Effects of Conjugation on Cytotoxicity, Tumor Specificity, and Long-Term Tumor Growth Suppression
    J. Med. Chem., 52, 2009, 241.

    79)  Biersack B., Diestel R., Jagusch C., Sasse F., Schobert R.,
    Metal complexes of natural melophlins and their cytotoxic and antibiotic activities
    J. Inorg. Biochem., 103, 2009, 72.




    78)  Biersack B., Diestel R., Jagusch C., Rapp G., Sasse F., Schobert R.,
    First syntheses of Melophlins P, Q, and R, and Effects of Melophlins on the Growth of Microorganisms and Tumor Cells
    Chemistry & Biodiversity, 5, 2008, 2423.

    77)  Schobert R., Biersack B., Knauer S., Ocker M.,
    Conjugates of the fungal cytotoxin illudin M with improved tumour specificity
    Bioorganic & Medicinal Chemistry, 16, 2008, 8592.

    76)  Bernhardt G., Biersack B., Bollwein S., Schobert R., Zoldakova M.,
    Terpene Conjugates of Diaminedichloridoplatinum(II) Complexes: Antiproliferative Effects in HL-60 Leukemia, 518A2 Melanoma, and HT-29 Colon Cancer Cells
    Chemistry & Biodiversity, 5, 2008, 1645.

    75)  Schobert R., Stehle R., Walter H.,
    Tipranavir analogous 3-sulfonylanilidotetronic acids: new synthesis and structure-dependant anti-HIV activity
    Tetrahedron, 64, 2008, 9401.

    74)  Schobert R., Kern W., Milius W., Ackermann T., Zoldakova M.,
    Synthesis of the first unnatural schisantherins and their effects in multidrug-resistant cancer cells
    Tetrahedron Lett., 49, 2008, 3359.

    73)  Schobert R., Schlenk A.,
    Tetramic and tetronic acids: An update on new derivatives and biological aspects
    Bioorganic & Medicinal Chemistry, 16, 2008, 4203.

    72)  Schobert R., Stangl A., Hannemann K.,
    Mixed catechol-hydroxamate and catechol-(o-hydroxy) phenacyl siderophores: synthesis and uptake studies with receptor-deficient Escherichia coli mutants
    Tetrahedron, 64, 2008, 1711.




    71)  Schobert R., Wicklein A.,
    Short syntheses of (-)-(R)-pyrrolam A and (1S)-1-hydroxyindolizidin-3-one
    Synthesis, , 2007, 1499.

    70)  Schobert R., Biersack B., Dietrich A., Grotemeier A., Müller T.,
    Monoterpenes as drug shuttles: cytotoxic (6-aminomethylnicotinate) platinum(II) complexes with potential to overcome cisplatin resistance
    J. Med. Chem, 50, 2007, 1288.

    69)  Schobert R., Bernhardt G., Biersack B., Bollwein S., Fallahi M., Grotemeier A., Hammond G.L.,
    Steroid Conjugates of Dichloro (6-aminomethylnicotinate) platinum(II): Effects on DNA, Sex Hormone Binding Globulin, the Estrogen Receptor, and Various Breast Cancer Cell Lines
    ChemMedChem, 2, 2007, 333.

    68)  Schobert R.,
    Domino syntheses of bioactive tetronic and tetramic acids
    Naturwissenschaften, 94, 2007, 1.




    67)  Schobert R., Dietrich M., Mullen G., Urbina-Gonzalez J.-U.,
    Phosphorus ylide based functionalizations of tetronic and tetramic acids
    Synthesis, , 2006, 3902.

    66)  Schobert R., Stangl A., Hannemann K.,
    Conjugates of methyl 6-aminopenicillinate with biscatechol hydroxamate chelators: synthesis and siderophoric activity
    Tetrahedron, 62, 2006, 7799.

    65)  Schobert R., Kempe R., Schmalz T., Gmeiner A.,
    Synthesis, structures and electrochemistry of some 1-(η2-allylamino)-1-ferrocenylcarbene complexes of chromium(0), molybdenum(0) and tungsten(0). Part 13: The chemistry of metallacyclic alkenylcarbene complexes
    J. Organomet. Chem., 691, 2006, 859.




    64)  Schobert R., Boeckman R. K. Jr., Pero J. E.,
    Preparation of (triphenylphosphoranylidene) ketene from (methoxycarbonylmethylene) triphenylphosphoran
    Organic Synthesis, 82, 2005, 140.

    63)  Schobert R., Jagusch C.,
    An Efficient Synthesis of Carlosic Acid and Other 5-Carboxymethyltetronates from Malates
    Synthesis, , 2005, 2421.

    62)  Schobert R., Jagusch C.,
    Solution-phase and solid-phase syntheses of enzyme inhibitor RK-682 and antibiotic agglomerins
    J. Org. Chem., 70, 2005, 6129.

    61)  Schobert R., Bieser A., Mullen G., Gordon G.,
    Domino conversions of allyl tetronates and 4-allyloxycoumarins to all-trans 1,3,4,5-tetrasubstituted γ-butyrolactams
    Tetrahedron Lett., 46, 2005, 5459.

    60)  Schobert R., Biersack B.,
    cis-Dichloroplatinum (II) complexes with aminoethylnicotinate and -isonicotinate ligands
    Inorg. Chim. Acta, 358, 2005, 3369.

    59)  Schobert R., Urbina-Gonzales J.,
    Annulated butanolides by ring closing metathesis of diallyltetronic acid derivatives
    Tetrahedron Lett., 46/21, 2005, 3657.

    58)  Schobert R., Jagusch C.,
    An expedient synthesis of 3-acyltetramic acids of the melophlin family from α-aminoesters and immobilized Ph3PCCO
    Tetrahedron, 61/9, 2005, 2301.

    57)  Schobert R., Stangl A.,
    Domino functionalizations of the amino terminus of 6-aminopenicillanates with Ph3CCO
    Tetrahedron Lett., 46, 2005, 1127.




    56)  Schobert R.,
    Applications of the Wittig Reaction in the Synthesis of Heterocyclic and Carbocyclic Compounds
    in Practical Approaches to Chemistry, Oxford University Press, , 2004, 129.

    55)  Schobert R., Jagusch C., Melanophy C., Mullen G.,
    Synthesis and reactions of polymer-bound Ph3P=C=C=O: a quick route to tenuazonic acid and other optically pure 5-substituted tetramates
    Org. Biomol. Chem., 2, 2004, 3524.

    54)  Schobert R., Schmalz T.,
    Introduction of a phosphorus ylide moiety into [η2-(ω-hydroxy)alkenyl] chromium(0) carbene complexes with Ph3CCO and consecutive Wittig alkenations with 2-alkynals. Part 12. The chemistry of metallacyclic alkenylcarbene complexes
    J. Organomet. Chem., 689, 2004, 2131.

    53)  Schobert R., Schmalz T.,
    Synthesis and selective silylation of ω-hydroxy functionalized (η2-alkenyl)-carbene complexes of chromium(0) and tungsten(0).  Part 11. The chemistry of metallacyclic alkenylcarbene complexes
    J. Organomet. Chem., 689, 2004, 1771.

    52)  Schobert R., Mangold A., Baumann T., Milius W., Hampel F.,
    Reactions of chelated η3-pentadienyl iron complexes with nucleophiles
    J. Organomet. Chem., 689, 2004, 575.

    51)  Schobert R., Gordon G. J., Mullen G., Stehle R. ,
    Microwave-accelerated Claisen rearrangements of allyl tetronates and tetramates
    Tetrahedron Lett., 45, 2004, 1121.




    50)  Schobert R., Stehle R., Milius W.,
    Hydroperoxide and Endoperoxide Lactones from Photooxygenation of 3-Alkylidenedihydrofuran-2,4-diones
    J. Org. Chem., 68, 2003, 9827.

    49)  Schobert R., Melanophy C., Maaref F., Hampel F.,
    An unusual hydrogenolysis of titana-2,9-dioxacyclonona-3,7-dienes producing cis-2-acylcyclopentanols
    Inorg. Chim. Acta, 355, 2003, 454.

    48)  Schobert R., Gordon G. J., Bieser A., Milius W.,
    3-Functionalized Tetronic Acids From Domino Rearrangement / Cyclization / Ring-Opening Reactions of Allyl Tetronates
    Eur. J. Org. Chem., , 2003, 3637.

    47)  Schobert R., Jagusch C.,
    Solid-phase domino syntheses of functionalized tetronates with Ph3P=C=C=O
    Tetrahedron Lett., 44, 2003, 6449.




    46)  Schobert R., Gordon G. J.,
    Bioactive Heterocycles from Domino Wittig-Pericyclic Reactions
    Curr. Org. Chem., 6, 2002, 1181.




    45)  Schobert R., Siegfried S., Gordon G. J.,
    Three-Component Synthesis of (E)-α,β-Unsaturated Amides of the Piperine Family
    Perkin Trans., 1, 2001, 2393.

    44)  Schobert R., Siegfried S., Weingaertner J., Nieuwenhuyzen M.,
    Oxidations of 3-Alkenyltetronic Acids with Dimethyldioxiran (DMD) and Air: Regioselectivity and Formation of a Spirotricyclic Hemiketal Endoperoxide Lactone
    Perkin Trans., 1, 2001, 2009.

    43)  Schobert R., Siegfried S., Gordon G. J., Mulholland D., Nieuwenhuyzen M.,
    Abnormal Claisen Rearrangements of Tetronates and Stereoselective Ring Opening of Intermediate Spirocyclopropanes
    Tetrahedron Lett., 42, 2001, 4561.

    42)  Schobert R., Siegfried S., Gordon G. J., Nieuwenhuyzen M., Allenmark S.,
    An Unusual Domino Claisen-Conia Reaction Producing 3,5-Dispirodihydrofuran-2,4-diones
    Eur. J. Org. Chem., , 2001, 1951.

    41)  Schobert R.,
    The Chemistry of Metallacyclic Alkenylcarbene Complexes X.
    Chelated η2-Alkene-and η3-Allyl-Carbene Complexes of Late Transition Metals: Structure-Reactivity Relations and Preparative Use
    J. Organomet. Chem., 617/8, 2001, 346.




    40)  Schobert R., Siegfried S., Nieuwenhuyzen M., Milius W., Hampel F.,
    Selective C-Acylation of CH-Active Dicarbonyl Compounds with Keteneylidenetriphenylphosphorane:
    Syntheses and Structures of 3-Triphenylphosphoranylideneacyltetronic acids,
    3-Triphenylphosphoranylidene-acyl-4-oxocoumarins and 4-Triphenylphosphoranylideneacylpyrazol-5-ones

    J. Chem. Soc., Perkin Trans., 1, 2000, 1723.

    39)  Schobert R., Siegfried S.,
    Regiospecific 4-O-Alkylation of Tetronic Acids with Isoureas
    Synlett, 2000, 686.

    38)  Nieuwenhuyzen M., Schobert R., Hampel F., Hoops S.,
    Reactions of Dicarbonyltitanocenes with 2-Diazo-1,3-diketones: O-,N- vs. O-,O - Chelation and Self Assembly of a Novel Heteroleptic Ti5O6 - Cage Compound
    Inorg. Chim. Acta, 304/1, 2000, 118.




    37)  Schobert R., Löffler J., Siegfried S.,
    Phosphacumulene Ylides as Versatile C2-Building Blocks: New Pathways to Tetronates, Coumarins and Azacycles
    Targets in Heterocyclic Systems, Vol. 2, (ed.: Italian Chemical Society), 1999.

    36)  Schobert R., Pfab H., Böhmer J., Hampel F., Werner A.,
    Preparative HPLC Resolution of Metallacyclic η3-Allyltricarbonyliron Complexes and Determination of the Absolute Configuration by X-Ray Crystal Structure Analysis
    J. Chem. Res, 1999, 578.

    35)  Eigemann S.-E., Schobert R.,
    The Chemistry of Metallacyclic Alkenylcarbene Complexes IX.
    Synthesis and Reactions of Chelated η2-Alkene-and η3-Allylcarbene Complexes of Cobalt, Manganese and Chromium
    J. Organomet. Chem., 585, 1999, 115.

    34)  Schobert R., Hampel F., Mangold A., Pfab H.,
    New Ferracyclic p- and η3-Pentadienyl Complexes by Carbonylative Lactonization of Unsaturated Diols
    Inorg. Chim. Acta, 291, 1999, 91.




    33)  Löffler J., Schobert R.,
    Cascade Syntheses with Cumulated Phosphorus Ylids. An Easy Entry to Highly Functionalized N-, O-, and S-Heterocycles
    Recent Res. Devel. in Org. and Bioorg. Chem., 2, 1998, 17.

    32)  Hampel F., Hommes N. v. E., Hoops S., Maaref F., Schobert R.,
    Novel Nine-membered Titanaheterocycles. - Structure, Ab Initio Calculations and Preparative Use towards the Selective Synthesis of Substituted Cyclopentanols
    Eur. J. Inorg. Chem., , 1998, 1253.

    31)  Böhmer J., Schobert R.,
    Synthesis of Oligo-enynes Using [Fe(alkene)(CO)n] Scaffolds. Z/E-Selective Wittig- and Horner-Type Olefination Reactions of β-Carbonyl Groups in η4-Diene and γ-Carbonyl Groups in η2-Alkene Complexes of Iron
    J. Chem. Res., 1998, 372.




    30)  Löffler J., Schobert R.,
    Synthesis of 1,3,4-Oxadiazoles from Carboxylic Hydrazides and of 1,2-Oxazin-6-ones from
    a-(Hydroxyimino) carboxylic Esters with Keteneylidene Triphenylphosphorane

    Synlett, 1997, 283.

    29)  Böhmer J., Förtsch W., Schobert R.,
    Selective Demetalations of Iron Diene Complexes. Expedient Synthesis of Substituted (Z)-Allylalcohols
    Synlett, 1997, 1073.

    28)  Förtsch W., Hampel F., Schobert R.,
    The Chemistry of Metallacyclic Alkenylcarbene Complexes VIII.
    Chelated Allylironcarbene Complexes with a Centrally Tethered p-Ligand. Syntheses and Reactions with Nucleophiles
    Chem. Ber., 130, 1997, 163.

    27)  Böhmer J.,Hampel F., Schobert R.,
    The Chemistry of Metallacyclic Alkenylcarbene Complexes VII.
    Regioselective Synthesis of Substituted (3E)-1,3-Dienes from Chelated (ω-Allyl) ironcarbene Complexes and Potassium Enoxyborates
    Synthesis, 1997, 661.

    26)  Schobert R.,
    The Chemistry of Metallacyclic Alkenylcarbene Complexes VI.
    C-C Bond Formation with Chelated Alkene-Carbene and Allyl-Carbene Complexes (Review)
    Trends in Organometallic Chemistry (series), 1997, Vol 2, 57.

    25)  Löffler J., Schobert R.,
    2(3H)-Oxazolones from a-Hydroxyamides and Keteneylidene Triphenylphosphorane via a Phosphorus Ylid Cascade
    Liebigs Ann. Chem., 1997, 217.




    24)  Förtsch W., Hampel F., Schobert R.,
    The Chemistry of Metallacyclic Alkenylcarbene Complexes V.
    Synthesis, Structure and SN2-Type Reactions of a Chelated (η2-Olefin) dioxocarbene Complex
    J. Organomet. Chem., 526, 1996, 169.

    23)  Löffler J., Schobert R.,
    Domino Syntheses of Five-, Six- and Seven-membered O-, N- and S-Heterocycles from α-,β-and γ-Substituted Carboxylic Esters
    J. Chem. Soc. Perkin Trans, 1, 1996, 2799.

    22)  Schobert R.,
    The Chemistry of Metallacyclic Alkenylcarbene Complexes IV.
    Unsaturated Metallacyclic Carbene Complexes as Flexible Tools in Organic Synthesis. Novel Rearrangement and Cascade Pathways to Functionalized Alkadienes, Carbo- and Heterocycles (Microreview)
    Chem. Ber., 129, 1996, 595.

    21)  Eigemann S.-E., Förtsch W., Hampel F., Schobert R.,
    Novel Synthesis of (Butatriene) Hexacarbonyldiiron Complexes. Stereochemical Aspects and an X-Ray Crystal Structure Determination
    Organometallics, 15, 1996, 1511.

    20) Böhmer J., Förtsch W., Hampel F., Schobert R.,
    The Chemistry of Metallacyclic Alkenylcarbene Complexes III.
    C-C Bond Formation with Carbon Nucleophiles. Stereoselective Dienylation of lithium Enolates and Cuprates and a Novel Cascade Synthesis of Highly Substituted Cyclopentenones from Lithium Acetylides
    Chem. Ber., 129, 1996, 427.




    19)  Schobert R., Müller S., Bestmann H.J.,
    One-pot Synthesis of α,γ-Disubstituted Tetronic Acids from α-Hydroxyallyl Esters: a Novel Tandem-Wittig-Claisen Reaction
    Synlett, 1995, 425.

    18)  Roth K.-D., Stöß M., Hampel F., Schobert R.,
    The Chemistry of Metallacyclic Alkenylcarbene Complexes II.
    Influence of the Central Metal on Structure, Reactivity and Electron Transfer Behaviour
    J. Organomet. Chem., 493, 1995, 113.

    17)  Schobert R., Maaref F., Dürr S.,
    One-pot Synthesis of Highly Substituted Cyclopentanolsvia Titanaheterocycles: Stereoselective Coupling Reactions of α,β-Unsaturated Aryl Ketones
    Synlett, 1995, 83.




    16)  Förtsch W., Hampel F., Schobert R.,
    The Chemistry of Metallacyclic Alkenylcarbene Complexes I.
    Synthesis, Crystal Structure and Reactions of Novel Metallacyclic Dioxo- and Aminooxocarbene Complexes of Iron
    Chem. Ber., 127, 1994, 711.




    15)  Dürr S., Höhlein U., Schobert R.,
    Novel Syntheses and Reactions of Unsaturated Titanaheterocycles
    J. Organomet. Chem., 458, 1993, 89.




    14)  Dürr S., Höhlein U., Schobert R.,
    Early Transition Metallocenes and Their Alkoxy Derivatives as Stoichiometric Reagents in Organic Synthesis
    GIT, 36, 1992, 906.

    13)  Dürr S., Höhlein U., Schobert R.,
    Unexpected Substitution Reactions of Bis (η5-cyclopentadienyl)-methyl (alkoxy)-,(acyloxy)- and
    -(chloro) titanium (IV) Complexes with Acids

    Organometallics, 11, 1992, 2950.

    12)  Höhlein U., Schobert R.,
    Synthesis of (η5-Cyclopentadienyl) dichloro-s-alkoxy-titanium (IV) Complexes. Assessment of the Reaction of Dichloro titanocene with Alcohols
    J. Organomet. Chem., 424, 1992, 301.




    11)  Schobert R.,
    Simple Synthesis and Reactions of Bis (cyclopentadienyl) methyl (alkoxy)- and -(acyloxy)-titanium(IV) Complexes
    J. Organomet. Chem., 405, 1991, 201.




    10)  Schobert R., Höhlein U.,
    Reduction and Isomerization of Epoxides and α-Diazoketones by Various Early Transition Metallocenes
    Synlett1990, 465.




    09)  Bestmann H.J., Schobert R.,
    Cumulated Ylids XX. Synthesis of (E)-α,α-Unsaturated Macrocyclic Lactones through Intramolecular Wittig Olefination with Keteneylidene Triphenylphosphorane
    Synthesis, 1989, 419.




    08)  Bestmann H.J., Schmidt M., Schobert R.,
    Cumulated Ylids XIX. Acylphosphonium Ylids by Chain-lengthening Difunctionalization of Grignard Compounds. Application to the Synthesis of (E)-α,β-Unsaturated Ketones and the Unique Substance
    Synthesis, 1988, 49.

    07)  Schobert R.,
    Reduction of Epoxides, α,β-Unsaturated Aldehydes and Vicinal Diketones by Reactive Titanocene
    Angew. Chem. Int. Ed. Engl., 27, 1988, 855.




    06)  Schobert R.,
    Oxidation of sec, sec - 1,2 - Diols to 1,2 - Diketones under Pfitzner-Moffatt Conditions
    Synthesis, , 1987, 741.

    05)  Bestmann H.J., Schobert R.,
    Total Synthesis of the Macrodiolide (R,R)-(-) - Grahamimycin A1
    Tetrahedron Lett., , 1987, 6587.




    04)  Bestmann H.J., Schmidt M., Schobert R.,
    Chain-lengthening Difunctionalization of Grignard Compounds by Reaction with Keteneylidene Triphenylphosphorane
    Angew. Chem. Int. Ed. Engl., 24, 1985, 405.

    03)  Bestmann H.J., Schobert R.,
    SeO2-Oxidation of α,β-Unsaturated Esters and Lactones to γ-Oxo or γ-Hydroxy Derivatives Synthesis of (rac)-A 26771 B and Norpyrenophorine
    Angew. Chem. Int. Ed. Engl., 24, 1985, 791.

    02)  Bestmann H.J., Schobert R.,
    Chemoselektive Mehrkomponentensynthese von α,β-ungesaettigten Estern und Lactonen sowie deren Diels-Alder-Addukten
    Angew. Chem. Int. Ed. Engl., 24, 1985, 791.




    01)  Bestmann H. J., Schobert R.,
    Neue Synthese macrocyclischer Lactone
    Angew. Chem. Int. Ed. Engl., 22, 1983, 780.



Verantwortlich für die Redaktion: André Wetzel

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